Diagnostic discovery for non-invasive, patient friendly and accurate disease diagnosis
Biosignatures was established in 2007 to address a global need for non-invasive, patient friendly and accurate disease diagnosis.
The company has developed a portfolio of products and has a growing body of evidence demonstrating their performance in blind tests. All the products under development are intended to bring significant improvements to current clinical best-practice. The goal is to enhance the experience of patients and reduce costs to healthcare providers through the replacement of complex, invasive and time-consuming biopsies with the analysis of small-volume blood samples.
Biosignatures uses proteomics (specifically the separation and analysis of proteins within blood samples) to identify patterns of proteins, or biosignatures, specific to a disease using statistical methods. It considers itself to be the first organisation in the world with the capability to reliably and cost effectively find new and highly valuable disease diagnostics using proteomics.
The company currently has one product in the clinic, BiopSave which has just passed its first independently blinded clinical trial. The company also has two products in pre-clinical development, with a focus on prostate, bladder and renal cancers.
Biosignatures’ unique capability to systematically and reliably discover new commercially viable diagnostics is driven by our deep understanding of the discovery process:
- All diagnostic development happens as clinical samples from day one
- Use appropriate sample sizes to achieve statistically relevant results
- Use strengths and limitations of machine learning to avoid the danger of over learning
- Rigorous process and quality control
Application of these principles allows Biosignatures to avoid the pitfalls which have made it surprisingly difficult to make advances in this area despite major investments.
In addition to negotiating, executing and managing licensing agreements with global businesses such as GE Healthcare, Waters Inc. & AstraZeneca, the team members built and sold Nonlinear Dynamics (a company specialising in image analysis and statistics for proteomic experiments) to Waters Inc. in 2013.
Will Dracup, CEO - over 25 years’ experience in commercial life sciences and computing. He founded Nonlinear Dynamics in 1989, created the initial products and led the business through to its sale to Waters Inc. in 2013. He was also a non-Executive Director of IDS PLC, an AIM-listed diagnostics business, for 5 years.
Dr David Bramwell, CTO - 20 years’ experience in commercial life sciences and IT. He has a 1st class M.Eng (hons) and a PhD in human visual perception. He joined Nonlinear Dynamics in 2000, led its software development from 2002 and has been responsible for the key insights behind Biosignatures’ technology.
Keith Milton, CFO – over 25 years’ experience in finance, holding CFO positions across a variety of sectors including computer software. Keith also has experience taking two businesses through to multi-million pound exits.
Market overview for the BiopSave product
The global In-Vitro Diagnostics market was estimated to be worth c.$70 billion per annum in 2017. Within this market, Biosignatures operates at the intersection of two fast growing sub-sectors – molecular diagnostics and proteomics.
It is estimated that around 100,000 prostate biopsies are performed per annum in the UK, more than 1 million per annum in the US. The number of prostate cancers diagnosed each year is, however, much smaller at around 40,000 per year in the UK and around 240,000 per year in the US.
A significant number of prostate biopsies could be safely avoided by using the BiopSave test, representing a significant cost benefit in addition to improved patient wellbeing.
Biosignatures will work with leading players in the diagnostics market using an industry-recognised commercial licensing model which the team has experience of managing. Each biosignature will be licensed as IP to a large diagnostic partner, who will develop a diagnostic test which uses the partner's proprietary hardware platform. Targeted partners will typically have these systems installed in hospitals worldwide.
Biosignatures started life in 2007 when it spun out of Nonlinear Dynamics Ltd.
Feel free to get in touch about any aspect of Biosignatures and our range of products